Síntese de compósitos/membranas P(VDFTrFE)/BaTiO3 associado ao peptídeo OGP para aplicações biomédicas

Abstract

Non-resorbable membranes are applied after the extraction and in order to act as a separator of the connective tissue bone tissue, forming a physical barrier, being a technique commonly known as Guided Bone Regeneration (GBR). DNA is more important to be exhibited as a characteristic responsible for a regeneration of bone tissue. The osteogenic peptide growth growth, OSTP (Growth Growth Peptide) associated with the bacterium emerges as an alternative, stimulates the process of bone formation through the bone bacterial membrane (BMPs), which in turn stimulates the process of bone formation. In this perspective, the work in development of a new material is the Poly (vinylidene-trifluoroethylene) Fluoride/Barium Titanate (P(VDFTrFE)/BaTiO3), added to the osteogenic growth peptide (OGP), which will provide more and enable the regeneration process. Different characterization methods were applied. The characterization of the materials was performed by the Scanning Electron Microscopy (SEM), by the Dispersive Energy Spectroscopy (EDS), by the X-ray Diffraction (XRD), by the Fourier Transform Spectroscopy (FTIR), by the Thermal Analysis (TGA)/DTG), Differential Scanning Calorimetry (DSC) and Contact Angle Measurements (θ) were applied using a profile detector and a moisture measurement system. The SEM results identified homogeneous particle shapes and sizes for the powder, so that the membranes presented a good matrix integration in the polymerization. X-ray diffraction that reveals high crystallinity of the results demonstrating its purity, for the composites/membranes crystal structure with characteristics in the β phase conferring a piezoelectricity of the material. The FTIR spectra confirm the XRD spectra as they evidence an expanded β phase due to a blend of the BaTiO3 ceramics in the polymer matrix. "Regarding the Angle of Contact", "Observe the values of decreases over time", "A hydrophilic surface in the composites / membranes". The chromatographic drivers confirm the degree of purity of the obtained OGP. The results of its disclosure were membranes A-1200, A-1500 and P-1200 released after 24 hours, 54 and 28% and the osteogenic growth peptide.