Utilização de poli(glicerol) dendrítico como transportador de cianocobalamina borilada para utilização na bnct

Abstract

The present work describes the synthesis and characterization of the poly (glycerol) and bored B12 vitamin (CbI-BPA/PGLDG4) conjugated. Such conjugated was conceived with focus on its utilization in the Boron Neutron Capture Therapy (BNCT), a radiotherapy technique applied mostly in brain tumors as the multiform glioblastoma. The BNCT consists in the administration, by the patient, of a compound that contains 10B in its composition followed by the application of a thermal neutron beam at the tumor. The techniques success depends on the deposition of 10B on the tumor cells, so that it deposits more on these cells than on the healthy ones. The boronphenylalanine (BPA) is one of the most studied compounds on the BNCT, because of its selective absorbability by some tumor cells and the fact that it is not toxic to the organism. Several studies have been trying to improve the boron delivery properties of compounds already used in this technique. In this work, B12 vitamin is used as a BPA delivery agent for tumor cells, since several studies show that the tumor cells have a large B12 absorption requirement for its quick multiplication, since it’s important for the basic metabolic processes. Connected with both compounds, BPA and B12 vitamin, the dendritic poly(glycerol) that will work as a boron’s delivery agent liberation system.