Resumo:
Rosacea is a fairly common dermatitis in the world population which primarily affects Caucasian women between 30 and 50 years old. When it comes to facial rosacea, the same causes functional and aesthetic discomfort to the patient since the diseased skin is sensitive and stands out when compared to a healthy skin. Thus, the present study aimed to obtain microspheres ivermectin based on arborescent polyglycerol MPGLDG4-IVE for the treatment of rosacea, a promising drug in topical rosacea treatments, with superior efficacy to other therapeutic formulations. The achievement of this conjugate aimed at the controlled and prolonged release of the drug. The methodology used to obtain the MPGLD-IVE microspheres was photoreticulation of a MPGLDG4 emulsion, previously reticulated with glycidyl methacrylate (MAG). The physical-chemical characterization of the spheres was made by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC), in addition to the drug’s in vitro release study. The results of the analysis showed that the emulsion obtained microspheres with a mean diameter of 20.3 μm, with a standard deviation of 6.7 μm. Finally, based on the study of the release of Ivermectin, it was detected that the type of diffusion transport is non-Fickian with release kinetics of 1.68 μg / mL per minute. The best reticulated time / yield is approximately 15 min and the best concentration of MAG in the reticulated of the complex favoring the release of ivermectin in 25 hours is 20%. Thus, it was concluded probably with the use of arborescent microspheres can reduce the harmful effects of rosacea in patients, requiring a smaller number of applications, with a reduced and more controlled drug dosage, reducing the chance of recurrence and consequent increase in life quality.
