Resumo:
In recent years, the use of therapeutic nanoparticles in cancer medicine has become
important in order to obtain the specific distribution of chemotherapeutic agents,
allowing the formulation of their own formulations. In this thesis the nanoparticles were
prepared for application in boron neutron capture therapy (BNCT) and anti angiogenesis therapy. Polyglycerol dendrimer (PGLD) was used as a nanoplatform in
this work because of its numerous advantages such as low toxicity and ease of
functionalization. In this thesis the synthesis and characterization of nanoparticles based
on PGLD for the treatment of head and neck cancer were performed. The polyglycerol
dendrimer was conjugated to the boro-curcumin complex (PGLDBC). Then it was
characterized by NMR (1H, 13C), FTIR and thermogravimetric analysis (TGA). The
nanoparticles obtained were incubated under in vitro conditions with tumor cells of the
SCC25 and SCC9 lines and their anticancer properties were evaluated by the TUNEL
technique with LC50 of 15,44 mg/mL and 4,74 mg/mL. Confirming the potential of
PGLDBC for the treatment of head and neck cancer.
